Glucophage should be taken with meals to reduce gastrointestinal side effects. Glucophage can cause lactic acidosis leading to hypoxic states and impairment of renal function.

Glucophage should not be administered in pregnant women and breast feeding mothers unless clearly indicated. Glucophage tablet should be taken as whole without chewing or crushing. Glucophage is not recommended in patients with active hepatic disease. It is advised to avoid alcohol intake while on Glucophage treatment as alcohol potentiates lactic acidosis. It is also recommended to perform regular renal and hematological tests.

Glucophage should not be used if you are receiving intravascular iodine as a part of radiation therapy as it can cause acute alteration of renal function. Glucophage should not be administered in pediatric patients below the age of 10. Glucophage is contraindicated in patients with renal disease and acute or chronic metabolic acidosis.