The frequency of diabetes is now equated to the epidemics of non-infectious diseases. The number of patients with diabetes is increased up to 3-5% each year. Thus, diabetes stands in one line with hypertension and coronary heart disease.
The history of Glucophage is now more than four decades, describing this drug as an effective and well tolerated medicine for the treatment of diabetes type 2. So it is not surprising at all. The recent clinical discoveries show that Glucophage is the only anti-diabetic medication that reduces the risk of death, associated with diabetes, and other serious complications caused by diabetes.
Glucophage is a modern medication, based on the active substance Metformin. Millions of people are common with the name Metformin and use it for the treatment of type 2 diabetes. Being a medicine of biguanides class, Metformin also copes with excess weight, and therefore is widely used for the weight loss.
Glucophage is sold at pharmacies under different tradenames: Metformin, Siofor, Bagomet, Metfogamma, Glykon, Metospanin, Glyformin, Gliminfor, Sofamet, Formetin, Langerin, Methadone, Formin Pliva, and NovoFormin.
Pharmacological actions of Glucophage
We may note some of the following pharmacological actions of Glucophage drug:
1. Glucophage reduces the blood glucose level, by inhibiting its production in liver and stimulating glucose uptake by muscles:
• Promotes the increased activity of insulin receptor tyrosine kinase
• Increases the activity of glycogen synthesis
• Contributes the movement of glucose transporters through the cell membrane
2. The weight of patients with type 2 diabetes, who take Glucophage, is not increased.
3. Therapy with Glucophage, alone or in combination with other drugs, it causes the positive effect on the lipid profile of blood serum.
4. Glucophage has a potential positive effect on the blood vessels:
• increases fibrinolysis (the process of blood clots dissolution)
• the decrease of viscosity and aggregation of platelets
• possible lowering of blood pressure and peripheral arterial resistance.
In general, Glucophage is the only anti-diabetic drug for monotherapy, which promotes a significant improvement of life quality and decrease the complications in type 2 diabetes. Glucophage is more effective for intake by young obese patients, and also has a protective effect on pre-diabetic state.
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