Glucophage Contraindications and Side effects

Use of GlucophageYou’d be surprised how many people suffer from diabetes today. This chronic disease destroys the life of thousands of people around the world. There are two types of diabetes, but the most common one is the second type – diabetes type 2. It is also called an “insulin-independent” type of diabetes.

Since the moment of insulin discovery, scientists have tried to synthesize this substance so the patients with diabetes could live. Nowadays, diabetic patients may live a normal live due to insulin injections and the use of special medications. Let’s starts from the beginning.
What actually happens in diabetes within the body? All food products contain proteins, fats and carbohydrates. These matters play a huge role in our bodies. Carbohydrates, derived from food, turn into glucose, under the influence of digestive juices. Glucose is a main source of energy for human body. Insulin is a substance that helps glucose to penetrate into the cells. So, diabetes is a disease in which our bodies aren’t capable to release insulin, or release it insufficiently.

When glucose cannot enter into the cells, it remains in blood, and therefore we say that a person has high blood sugar if he is sick with diabetes. Insulin injections help to balance the blood sugar level as well as oral medications, such as Glucophage. This medicine was invented quite recently and has already gained a huge popularity among the patients. Glucophage is just a trade name of an active substance Metformin.

Metformin is appointed in:

  1. diabetes type 2 in adults (when the diet is not effective at all, obesity)
  2. In combination with insulin when a person has diabetes type 2.

Period of Glucophage therapy

Glucophage belongs to biguanides that cause the decrease of glucose absorption in the intestinal tract. Biguanides are usually prescribed to people with excess weight, who cannot lose extra pounds without medical help. Usually these drugs are: Metformin, Avandamet, Glucophage and Metfogamma. The dosage is indicated individually. But the initial dose is usually Glucophage 500mg (1 pill) a day, the maximal dose is 3mg / day. After 10-15 days the dose may be increased but with the help of a doctor and depends on the level of hypoglycemia. Doctors give advice to divide the daily dose of Glucophage into 2-3 intakes, to avoid and side effects. Glucophage pills are to be taken orally during the meal or soon after the meal.

Before taking any drug, every man should know the whole information about this problem.

For example, if you have:

  • kidney dysfunction;
  • acute disease (causing the risk of kidney dysfunction: dehydration, fever, infectious disease, etc.);
  • pronounced manifestations of hypoxia (respiratory insufficiency, heart failure, myocardial infarction);
  • serious traumas and surgical interference;
  • chronic alcoholism and acute alcohol intoxication;
  • lactic acidosis;
  • pregnancy;
  • breastfeeding;
  • increased hypersensitivity to the drug.

These are contraindications for use of Glucophage (Metformin). If you have any of these conditions, you should consult a doctor. During the period of Glucophage therapy, the doctor should examine liver and kidneys function. In case of overdosing it is recommended to stop taking Metformin and change it into insulin consumption. Patients should never take alcohol if they are taking the treatment course with Glucophage.

Glucophage may provoke some side effects in the gastrointestinal tract: nausea, vomiting, diarrhea, metallic taste in the mouth, appetite loss, flatulence or stomach pain (occurring at the beginning of the therapy and pass soon).

Side effects in metabolism: lactic acidosis, hypovitaminosis of B12 (malabsorption) and skin rash.

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